Using Nano Technology to increase Bio Availability at the Blood-Brain Barrier
Nano Technology is the science of increasing the surface area of a molecule by breaking clusters of molecules into smaller pieces. Another way to look at a real-life visual is to take a cluster of grapes and break them into individual grapes. The single grapes have a greater bio-availability then a cluster of grapes. So, if you took the cannabinoids in a THC molecule and there are a million THC molecules in a single cluster, then the cluster can only hook up with a handful of receptors because most of the molecules are buried in the cluster. But if you break them into a million molecules, then you can get a million THC molecules on a million receptors. This also produces a more stable bond as the molecules are smaller and less likely to be bumped off by other molecules floating through the bloodstream.
Another factor is that items bigger than 200 nanometers do not get through the blood-brain barrier. The average THC molecular cluster is between 400 nanometers and 1,000 nanometers. Our Nano Technology process takes the average molecule down to a size less the 40 nanometers. This allows the molecules to float right through the brain filter and bring the THC molecules in contact with the brain receptors.
Cannabinoids, primarily THC and CBD, suppress pain through multiple mechanisms that involve both the CB1 and the CB2 cannabinoid receptors located in the peripheral tissues of the spinal area and the brain. In the brain stem and the thalamus, there are a lot of CB1 receptors that are keyed mostly for THC and they will block the perception of pain. The cannabinoids working through these CBD receptors can reduce inflammation as well as hyperallergic effects where you have too much response to pain.
But also, the THC, which is considered the heavy carrier for pain relief, works through sensory nerves that are able to decrease the pain signals that would go to the spinal cord and the brain where you interpret pain. So, when you take THC in the RĒL delivery system to reach these areas, it can suppress the pain signal processes, called the GABAergic process.
There’re also some other secondary mechanisms involving the pro-inflammatory processes as well as the opium beta-endorphin receptors. Terpenes, the essential oils found in the trichomes of the cannabis plant, are also very analgesic and very anti-inflammatory on their own accord. So, the cannabinoids suppress the transmission and interpretation of pain in a way that can oftentimes provide an alternative, for example, to opioids, which have a lot of addictive risks and adverse effects.